TREM2 Antibody

Product Specifications

Background

Triggering receptor expressed on myeloid cells 2, TREM2, is a type I transmembrane innate immune receptor predominantly expressed by microglia in the central nervous system and is genetically linked to the risk for Alzheimer’s disease (Schmid, C.D., et al., 2002) . TREM2 has been shown to be a specific marker for alternatively activated microglia known as M2 cells (Cherry, J.D. et al., 2014) . TREM2 binds to its adaptor, DNAX-activating protein (DAP12) on the surface of microglia to enact innate immune responses and downstream cellular responses or signaling pathways (Jay, T.R, et al., 2017) . TREM2 has important roles in microglial phagocytosis of apoptotic neurons, damaged myelin, and amyloid plaques (Gratuze, M., et al., 2018) . In early brain development, TREM2 is essential for synaptic pruning (Filipello, F. et al., 2018) .

Synonyms

Triggering receptor expressed on myeloid cells 2

Gene ID

54209

Swiss Prot

Q9NZC2

Host

Rabbit

Cross Reactivity

Mouse

Target

TREM2

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

Recombinant human TREM2 protein expressed in and purified from E. Coli.

Applications

Purification

Antigen Affinity purification from Pooled whole antiserum

Concentration

Lot Dependent

Dilution

WB (1:300-5000)

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Unmodified

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.