Serotonin Transporter (Thr276) Antibody

The serotonin transporter (SERT) recycles serotonin by transporting it back to the pre-synaptic cell. It is the primary target for most anti-depressant drugs and for stimulants such as methamphetamines. SERT is regulated by several processes, including a cyclic GMP signaling pathway involving nitric oxide synthase, guanylyl cyclase, and cGMP-dependent protein kinase (PKG) . cGMP- and PKG-mediated SERT regulation requires phosphorylation at Thr-276 (Ramamoorthy et al., 2007) . It has been suggested that although PKG is involved in the stimulation of SERT at Thr-276, it does not directly phosphorylate the residue, rather it initiates a kinase cascade that leads to SERT phosphorylation by an as yet unidentified protein kinase (Wong et al., 2012) . Also of therapeutic importance, mutation at the Thr-276 residue has been shown to decrease the potency of a variety of anti-depressant drugs, (Zhang YW and Rudnick G, 2005) .

5 HTT antibody, 5 HTTLPR antibody, 5 hydroxytryptamine (serotonin) transporter antibody, 5 hydroxytryptamine transporter antibody, 5HT transporter antibody, 5HTT antibody, hSERT antibody, HTT antibody, Na+/Cl- dependent serotonin transporter antibody, OCD1 antibody, SC6A4_HUMAN antibody, Serotonin transporter 1 antibody, SERT antibody, SERT1 antibody, Slc6a4 antibody, Sodium dependent serotonin transporter antibody, Sodium-dependent serotonin transporter antibody, Solute carrier family 6 (neurotransmitter transporter) member 4 antibody, solute carrier family 6 (neurotransmitter transporter serotonin) member 4 antibody, Solute carrier family 6 member 4 antibody

Specific for endogenous levels of the ~76 kDa SERT protein phosphorylated at Thr276. Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide.