Prosurfactant Protein C Antibody
Product Specifications
Background
Pulmonary surfactant Protein C (SP-C) is one of 4 distinct surfactant proteins; SP-A, SP-B, SP-C and SP-D. SP-C is produced by proteolytic cleavage of a larger precursor known as Prosurfactant Protein C which is expressed exclusively in the lungs and widely used as a marker for alveolar type 2 epithelial cells. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency and are associated with interstitial lung disease in older infants, children, and adults.
Synonyms
BRICD6 antibody, BRICHOS domain containing 6 antibody, PSP C antibody, PSPC antibody, PSPC_HUMAN antibody, Pulmonary surfactant apoprotein 2 antibody, Pulmonary surfactant apoprotein PSP C antibody, pulmonary surfactant apoprotein-2 SP-C antibody, Pulmonary surfactant associated protein C antibody, Pulmonary surfactant associated proteolipid SPL pVal antibody, Pulmonary surfactant associated proteolipid SPL (Val) antibody, Pulmonary surfactant protein SP5 antibody, Pulmonary surfactant-associated protein C antibody, Pulmonary surfactant-associated proteolipid SPL (Val) antibody, SFTP 2 antibody, SFTP2 antibody, SFTPC antibody, SFTPC surfactant pulmonary associated protein C antibody, SMDP2 antibody, SP 5 antibody, SP C antibody, SP-C antibody, SP5 antibody, SPC antibody, Surfactant associated protein pulmonary 2 antibody, Surfactant protein c antibody, Surfactant proteolipid SPL-pVal antibody, Surfactant pulmonary associated protein C antibody
Swiss Prot
P21841
Host
Rabbit
Cross Reactivity
Mouse
Target
Prosurfactant Protein C
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
Synthetic peptide from the N-terminal region of mouse Prosurfactant Protein C.
Applications
IHC
Purification
Antigen Affinity purification
Concentration
Lot Dependent
Dilution
IHC ()
Buffer
PBS
Modification
Unmodified
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Specificity
Specific for endogenous levels of the ~21 kDa Prosurfactant Protein C.
Predicted Cross Reactivity
Human
Curated Selection
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