PAK-1 (Thr84) Antibody

PAKs, p21 activated kinases, are a family of serine/threonine protein kinases comprised of six isoforms, PAK1-6, and they play important roles in cytoskeleton dynamics, cell survival and proliferation (Ye et al, 2012) . Each of these isoforms contains a C-terminal catalytic domain and an N-terminal regulatory domain with a small G protein binding motif (Chen et al, 2004) . OSR1, oxidative stress response 1, is activated only by osmotic stresses, like sorbital or NaCl (Chen et al, 2004) . It has been predicted that OSR1 phosphorylates PAK1 in the regulatory domain at thr84 and inhibits activation of JNK and MAPK pathway. (Chen et al, 2004) . It has also been suggested that OSR1 may have a regulating function with actin cytoskeleton because it can phosphorylate PAK1 at Thr-84 and bind to gelsolin (Chen et al, 2004) .

ADRB2 antibody, Alpha PAK antibody, Alpha-PAK antibody, MGC130000 antibody, MGC130001 antibody, p21 activated kinase 1 antibody, p21 protein (Cdc42/Rac) activated kinase 1 antibody, p21-activated kinase 1 antibody, p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related) antibody, p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) antibody, p65 PAK antibody, p65-PAK antibody, P68-PAK antibody, PAK alpha antibody, PAK-1 antibody, Pak1 antibody, PAK1_HUMAN antibody, Paka antibody, PAKalpha antibody, Protein kinase MUK2 antibody, Rac/p21-activated kinase antibody, Serine/threonine-protein kinase PAK 1 antibody, STE20 homolog yeast antibody

Specific for endogenous levels of the ~68 kDa PAK1 phosphorylated at Thr84. The immunolabeling is completely eliminated by treatment with λ-phosphatase.