Mnk2a Antibody
Product Specifications
Background
MAP kinase-interacting kinases Mnk1 and Mnk2 are activated by the MAP kinases, ERK and p38 (Waskiewicz et al., 1997) . Additionally, Mnk1 and Mnk2 have been shown to phosphorylate the translation initiation factor eIF4E (Fukunaga and Hunter 1997; Waskiewicz et al., 1997) . Alternative splicing of the MKNK2 gene results in two isoforms with different C-termini: one that has a MAPK-binding domain, Mnk2a, and one that does not, Mnk2b (Parra et al., 2005) . Recent studies have indicated that Mnk2a has tumor suppressive activity while Mnk2b is pro-oncogenic (Maimon et al., 2014) .
Synonyms
ADCAD1 antibody, MADS box transcription enhancer factor 2 polypeptide A (myocyte enhancer factor 2A) antibody, MEF2 antibody, MEF2A antibody, MEF2A_HUMAN antibody, Myocyte enhancer factor 2A antibody, Myocyte-specific enhancer factor 2A antibody, RSRFC4 antibody, RSRFC9 antibody, whole antiserum response factor like protein 1 antibody, whole antiserum response factor-like protein 1 antibody
Gene ID
2872
Swiss Prot
Q9HBH9
Host
Rabbit
Cross Reactivity
Human
Target
Mnk2a
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
Synthetic peptide from the C-terminal region, specific to the human Mnk2a isoform. The sequence of the antigen has no homology with Mnk1 or Mnk2b.
Applications
WB
Purification
Antigen Affinity purification from Pooled whole antiserum
Concentration
Lot Dependent
Dilution
WB (1:300-5000)
Buffer
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Modification
Unmodified
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Product Datasheet
https://www.biossantibodies.com/datasheets/bs-70162R
Specificity
Specific for endogenous levels of the ~52 kDa Mnk2a protein. Immunolabeling is blocked by preadsorption with the Mnk2a peptide used as antigen, but not by Mnk2b peptide.
Gene ID URL
2872
Predicted Cross Reactivity
Non-Human Primate
Curated Selection
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