Hsp70 (Ser153) Antibody

The Hsp70 family of heat shock proteins are considered stress-induced survival proteins as they are expressed when exposed to factors such as heat, hypoxia, oxidative stress, altered pH or by underlying factors like cancer (Daugaard et al. 2007) . Hsp70 proteins are able to bind hydrophobic residues on misfolded proteins, thereby preventing their aggregation and thus serving important roles in protein homeostasis. To date, there have been 8 members of the family identified; the majority of which are found in the cytosol though some have specific function in tissue or an organelle (Murphy, 2013) . Hsp70 has also been shown to play a major role in cancer; from tumor grade to prognosis, as well as chemotherapeutic drug resistance (Ciocca et al, 2005) . There have been several phospho-serine and threonine sites identified within Hsp70, the role of each one has yet to be determined.

DnaK type molecular chaperone HSP70 1 antibody, Epididymis secretory protein Li 103 antibody, FLJ54303 antibody, FLJ54370 antibody, FLJ54392 antibody, FLJ54408 antibody, FLJ75127 antibody, Heat shock 70 kDa protein 1 antibody, Heat shock 70 kDa protein 1/2 antibody, Heat shock 70 kDa protein 1A antibody, Heat shock 70 kDa protein 1A/1B antibody, Heat shock 70kDa protein 1B antibody, Heat shock induced protein antibody, HEL S 103 antibody, HSP70 1 antibody, HSP70 1A antibody, HSP70 1B antibody, HSP70 2 antibody, HSP70-1 antibody, HSP70-1/HSP70-2 antibody, HSP70-1A antibody, HSP70.1 antibody, HSP70.1/HSP70.2 antibody, HSP71_HUMAN antibody, HSP72 antibody, HSPA1 antibody, HSPA1A antibody, HSPA1B antibody

Specific for the ~70 kDa Hsp70 phosphorylated at Ser153. Immunolabeling of Hsp70 is completely eliminated with λ-phosphatase treatment. Additional bands detected are thought to be other members of the Hsp70 family.