GluR2/3 Antibody

Product Specifications

Background

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR) . The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990; Hollmann and Heinemann, 1994) . The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory (Duprat et al., 2003; Seidenman et al., 2003; Chung et al., 2003; Yan et al., 2002) .

Synonyms

AMPA selective glutamate receptor 2 antibody, AMPA selective glutamate receptor 3 antibody, GluR K2 antibody, GluR K3 antibody, GLURB antibody, GLURC antibody, GLUTAMATE RECEPTOR 2 antibody, GLUTAMATE RECEPTOR 3 antibody, Glutamate receptor ionotropic AMPA 2 antibody, Glutamate receptor ionotropic AMPA 3 antibody, GRIA2 antibody, GRIA3 antibody

Gene ID

29627

Swiss Prot

P19491

Host

Rabbit

Cross Reactivity

Rat

Target

GluR2/3

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GluR2/3, conjugated to keyhole limpet hemocyanin (KLH) .

Applications

Purification

Antigen Affinity purification from Pooled whole antiserum

Concentration

Lot Dependent

Dilution

WB (1:300-5000)

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Unmodified

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.