GABAB Receptor (Ser923), R1-Subunit Antibody

Product Specifications

Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABA-A and the GABA-B subtype of receptors. GABA-B receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Phosphorylation enhances GABA-B receptor effector coupling (Couve et al., 2004) . Phosphorylation of Ser-923 is thought to be important in the regulation of GABA-B receptor function.

Synonyms

DJ271M21.1.1 antibody, dJ271M21.1.2 antibody, FLJ92613 antibody, GABA-B receptor 1 antibody, GABA-B-R1 antibody, GABA-BR1 antibody, GABAB R1 antibody, GABAB subunit 1c antibody, GABABR1 antibody, GABBR1 3 antibody, GABBR1 antibody, GABR1_HUMAN antibody, Gamma aminobutyric acid (GABA) B receptor 1 antibody, Gamma-aminobutyric acid type B receptor subunit 1 antibody, Gb1 antibody, GPRC3A antibody, Seven transmembrane helix receptor antibody

Gene ID

81657

Swiss Prot

Q9Z0U4

Modification Site

Ser923

Host

Rabbit

Cross Reactivity

Mouse, Rat

Target

GABAB Receptor (Ser923), R1-Subunit

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser923 of the R1-subunit of rat GABAB receptor, conjugated to keyhole limpet hemocyanin (KLH) .

Applications

Purification

Antigen Affinity purification from Pooled whole antiserum

Concentration

Lot Dependent

Dilution

WB (1:300-5000)

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Phosphorylation

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Specificity

Specific for endogenous levels of the ~102 kDa GABAB R1 phosphorylated at Ser923. Immunolabeling is completely eliminated by treatment with λ-phosphatase.