Clavesin Antibody

Product Specifications

Background

Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009) . Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008) .

Synonyms

4 antibody, C6orf212 antibody, C6orf213 antibody, Clavesin 1 antibody, Clavesin 2 antibody, CRALBPL antibody, FLJ37248 antibody, MGC120572 antibody, MGC34646 antibody, OTTHUMP00000017122 antibody, Retinaldehyde binding protein 1 like 1 antibody, Retinaldehyde binding protein 1 like 2 antibody, RLBP1L1 antibody, RLBP1L2 antibody

Gene ID

366311

Swiss Prot

A6JFQ6

Host

Rabbit

Cross Reactivity

Rat

Target

Clavesin

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat Clavesin 1, conjugated to keyhole limpet hemocyanin (KLH) .

Applications

Purification

Affinity purification

Concentration

Lot Dependent

Dilution

WB (1:300-5000)

Buffer

PBS + 50% glycerol

Modification

Unmodified

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Specificity

Specific for endogenous levels of the ~35 kDa clavesin 1/2 protein doublet. Isoform-specific knock down in cultured hippocampal neurons indicates that the lower and upper bands are clavesin 1 and 2, respectively.