Amyloid Precursor Protein Antibody

Product Specifications

Background

A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) (Kamenetz et al., 2003) . The phosphorylation of APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001) .

Synonyms

A4 amyloid protein antibody, A4_HUMAN antibody, AAA antibody, ABETA antibody, ABPP antibody, AD1 antibody, AICD-50 antibody, AICD-57 antibody, AICD-59 antibody, AID (50) antibody, AID (57) antibody, AID (59) antibody, Alzheimer disease amyloid protein antibody, Amyloid beta (A4) precursor protein antibody, Amyloid beta A4 protein antibody, Amyloid beta protein antibody, Amyloid intracellular domain 50 antibody, Amyloid intracellular domain 57 antibody, Amyloid intracellular domain 59 antibody, Amyloid precursor protein antibody, APP antibody, APPI antibody, Beta amyloid peptide antibody, Beta-amyloid precursor protein antibody, Beta-APP40 antibody, Beta-APP42 antibody, C31 antibody, Cerebral vascular amyloid peptide antibody, CTFgamma antibody, CVAP antibody, Gamma-CTF (50) antibody, Gamma-CTF (57) antibody, Gamma-CTF (59) antibody, peptidase nexin II antibody, PN 2 antibody, PN II antibody, PN-II antibody, PN2 antibody, PreA4 antibody, Protease nexin II antibody, Protease nexin-II antibody, S-APP-alpha antibody, S-APP-beta antibody

Gene ID

54226

Swiss Prot

P08592

Host

Rabbit

Cross Reactivity

Mouse, Rat

Target

Amyloid Precursor Protein

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat APP, conjugated to keyhole limpet hemocyanin (KLH) .

Applications

Purification

Antigen Affinity purification from Pooled whole antiserum

Concentration

Lot Dependent

Dilution

WB (1:300-5000)

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Unmodified

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Specificity

Specific for endogenous levels of the ~115 kDa APP protein. Immunolabeling of the APP protein band is completely blocked by preadsorption of the antibody with the peptide used as antigen.