AKT (Thr342) Antibody

The serine/threonine kinase Akt also known as protein kinase B (PKB) or Rac, plays a crucial role in controlling many diverse and important cellular functions such as cell survival and glycogen metabolism (Hajduch et al., 2001 and Nicholson & Anderson, 2002) . Three isoforms (α, β, and γ) have been identified that can be activated rapidly in response to insulin and growth factors in a phosphoinositide 3-kinase (PI3K) -dependent fashion (Hajduch et al., 2003) . Phosphorylation of Aktα occurs at two specific regulatory sites in Drosophila, one localized in the kinase domain, Thr342, and the other in the C-terminal regulatory domain, Ser505: these two activation sites are homologous to mammalian Ser473 and Thr308 respectively (Powell et al., 2004) .

AKT1 antibody, AKT1_HUMAN antibody, AKT2 antibody, AKT3 antibody, PKB alpha antibody, PKB antibody, PKB beta antibody, PKBalpha antibody, PRKBA antibody, PRKBB antibody, PRKBG antibody, Protein kinase B antibody, Protein kinase B beta antibody, Protein kinase B gamma antibody, Proto-oncogene c-Akt antibody, RAC alpha antibody, RAC antibody, RAC gamma antibody, RAC PK alpha antibody, RAC PK beta antibody, RAC PK gamma antibody, RAC-alpha serine/threonine-protein kinase antibody, RAC-PK-alpha antibody, STK2 antibody

Specific for endogenous levels of the ~68 kDa AKT protein phosphorylated at Thr342. Immunolabeling is completely eliminated with λ-phosphatase treatment. It has been reported that this antibody may also recognize some level of phosphorylated S6K as there is 67% homology with the sequence used as antigen.