CCDC98 Polyclonal Antibody, PE Conjugated
Product Specifications
Background
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Synonyms
ABRA1; CCDC98; BRCA1-A complex subunit Abraxas; Coiled-coil domain-containing protein 98; Protein FAM175A; FAM175A; UNQ496/PRO1013
Gene ID
84142
Swiss Prot
Q6UWZ7
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
51-150/409
Target
CCDC98
Clonality
Polyclonal
Isotype
IgG
Conjugation
PE
Source
KLH conjugated synthetic peptide derived from human CCDC98
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
496,564nm/578nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
84142
Predicted Cross Reactivity
Human, Rat, Dog, Cow, Sheep, Pig, Horse, Chicken
Curated Selection
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