CCDC98 Polyclonal Antibody, Cy3 Conjugated
Product Specifications
Background
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Synonyms
ABRA1; CCDC98; BRCA1-A complex subunit Abraxas; Coiled-coil domain-containing protein 98; Protein FAM175A; FAM175A; UNQ496/PRO1013
Gene ID
84142
Swiss Prot
Q6UWZ7
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
51-150/409
Target
CCDC98
Clonality
Polyclonal
Isotype
IgG
Conjugation
Cy3
Source
KLH conjugated synthetic peptide derived from human CCDC98
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
512,550nm/570,615nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
84142
Predicted Cross Reactivity
Human, Rat, Dog, Cow, Sheep, Pig, Horse, Chicken
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
585414-02 100 µg
Mitochondrial Fission Factor, Recombinant, Human, aa1-322, His-Tag
Ask
View Details MBS6267147-01 0.1 mL
MART-1, multiple clones (+2) (Melanoma Antigen Recognized by T-cells 1, Melan-A) (BSA & Azide Free) (MaxLight 405)
Ask
View Details MBS6267147-02 5x 0.1 mL
MART-1, multiple clones (+2) (Melanoma Antigen Recognized by T-cells 1, Melan-A) (BSA & Azide Free) (MaxLight 405)
Ask
View Details