NALP4 Polyclonal Antibody, AbBy Fluor™ 680 Conjugated
Product Specifications
Background
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.
Synonyms
NACHT, LRR and PYD domains-containing protein 4; Cancer/testis antigen 58; CT58; PAAD and NACHT-containing protein 2; PAN2; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; PYPAF4; Ribonuclease inhibitor 2; NLRP4; NALP4; RNH2
Gene ID
147945
Swiss Prot
Q96MN2
Cellular Locus
Cytoplasm, Secreted, Extracellular matrix
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
351-450/994
Target
NALP4
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 680
Source
KLH conjugated synthetic peptide derived from human NALP4
Applications
IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
679nm/702nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Specificity
This antibody will detect multiple forms of NALP4, including the A, C and E Mouse variants.
Gene ID URL
147945
Predicted Cross Reactivity
Pig, Horse
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
033431-Biotin 200 µL
CCR5, ID (CCR5, CMKBR5, C-C chemokine receptor type 5, CHEMR13, HIV-1 fusion coreceptor, CD195) (Biotin) discontinued
Ask
View Details MBS1189009-01 0.02 mg (E-Coli)
Recombinant Shewanella sp. Thymidine phosphorylase (deoA)
Ask
View Details 
MBS1189009-02 0.02 mg (Yeast)
Recombinant Shewanella sp. Thymidine phosphorylase (deoA)
Ask
View Details 
MBS1189009-03 0.1 mg (E-Coli)
Recombinant Shewanella sp. Thymidine phosphorylase (deoA)
Ask
View Details MBS1189009-04 0.1 mg (Yeast)
Recombinant Shewanella sp. Thymidine phosphorylase (deoA)
Ask
View Details 
MBS1189009-05 0.02 mg (Baculovirus)
Recombinant Shewanella sp. Thymidine phosphorylase (deoA)
Ask
View Details