What is the catalog number for Voacamine?

The catalog number for Voacamine is HY-N6932.

What sizes are available for Voacamine?

Voacamine is available in the following size(s): 1 mg, 5 mg, 10 mg.

How many pack sizes does Voacamine come in?

Voacamine is available in 3 different pack sizes.

Is Voacamine in stock?

Voacamine is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Voacamine?

Voacamine is manufactured by QuantiMol.

What is the estimated delivery time for Voacamine?

Estimated delivery time for Voacamine is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Voacamine?

The safety data sheet for Voacamine is available here: http://file.medchemexpress.com/batch_PDF/HY-N6932/Voacamine-SDS-MedChemExpress.pdf.

Voacamine

Voacamine is an indole alkaloid with cannabinoid 1 (CB1) antagonistic activity. Voacamine can inhibit nuclear translocation. Voacamine is effective in enhancing the effect of Doxorubicin as it interferes with the P-glycoprotein (P-gp) function. Voacamine promotes apoptosis-independent autophagic cell death in human osteosarcoma cells. Voacamine activates mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K/Akt/mTOR signaling pathway to suppress breast cancer progression. Voacamine inhibits EGFR to exert oncogenic activity against colorectal cancer[1][2][3][4][5].

Product Specifications

CAS Number

3371-85-5

UNSPSC

12352005

Target

Akt; Apoptosis; Autophagy; Cannabinoid Receptor; EGFR; mTOR; P-glycoprotein; PI3K

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; GPCR/G Protein; JAK/STAT Signaling; Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/voacamine.html

Purity

99.64

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(OC)[C@]1([C@@H]2[N@](CC(C[C@H]2CC)C1)CC3)C4=C3C(C=C5OC)=C(N4)C=C5[C@](C[C@@H]6[C@H](C(OC)=O)[C@H](N(C)C/C6=C/C)C7)([H])C8=C7C9=C(N8)C=CC=C9

Molecular Formula

C43H52N4O5

Molecular Weight

704.90

References & Citations

[1]Kitajima M, et al. Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity. Bioorg Med Chem Lett. 2011 Apr 1;21 (7) :1962-4.|[2]Pellegrini, E., et al., (2022) . A natural product, voacamine, sensitizes paclitaxel-resistant human ovarian cancer cells. Toxicology and applied pharmacology, 434, 115816.|[3]Zuo, Y., et al., (2022) . Activation of mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K/Akt/mTOR signaling pathway by voacamine suppress breast cancer progression. Phytomedicine : international journal of phytotherapy and phytopharmacology, 99, 154015. |[4]Meschini, S., et al., (2008) . The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells. Autophagy, 4 (8), 1020–1033. |[5]Chen, Y., et al., (2022) . Voacamine is a novel inhibitor of EGFR exerting oncogenic activity against colorectal cancer through the mitochondrial pathway. Pharmacological research, 184, 106415.