Tadalafil

Tadalafil (IC-351) is a PDE5 inhibitor with an IC50 value of 1.8 nM.

Product Specifications

CAS Number

[171596-29-5]

Product Name Alternative

IC-351

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Tadalafil.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : ≥ 52 mg/mL

Smiles

O=C([C@@]1([H])CC2=C([C@@H](C3=CC=C(OCO4)C4=C3)N15)NC6=C2C=CC=C6)N(C)CC5=O

Molecular Formula

C22H19N3O4

Molecular Weight

389.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Blount MA, et al. Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation. Mol Pharmacol. 2004 Jul;66 (1) :144-52.|[2]Yang Y, et al. Effect of acute tadalafil on sperm motility and acrosome reaction: in vitro and in vivo studies. Andrologia. 2013 Apr 14. [Epub ahead of print]|[3]Mostafa ME, et al. Effect of Chronic Low-dose Tadalafil on Penile Cavernous Tissues in Diabetic Rats. Urology. 2013 Jun;81 (6) :1253-60.