BMS-986299
BMS-986299 (compound 112) is a first-in-class NLRP3 inflammasome agonist with an EC50 of 1.28 μM. (patent WO2018152396A1) .
Product Specifications
CAS Number
[2242952-69-6]
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bms-986299.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(C)N(CC)CC1=NC2=C(N1)C3=C(C=C(C4=NNC=C4)C=C3)N=C2N
Molecular Formula
C18H19N7O
Molecular Weight
349.39
References & Citations
[1]Gary Glick, et al. Substituted imidazo-quinolines as nlrp3 modulators. WO2018152396A1.|[2]Gao G, et al., Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro. Front Pharmacol. 2022 Jul 5;13:906548.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
NLRP3
Available Sizes
Curated Selection
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