FOXL2 Polyclonal Antibody
Product Specifications
Background
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis throught transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity) . Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity) . Is a regulator of CYP19 expression (By similarity) . Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity) . Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Synonyms
Blepharophimosis; Blepharophimosis epicanthus inversus and ptosis 1; Blepharophimosis epicanthus inversus and ptosis; BPES 1; BPES; BPES1; epicanthus inversus and ptosis 1; forkhead box L2; Forkhead box protein L2; forkhead transcription factor FOXL2; FOX L2; FOXL 2; FOXL2; FOXL2_HUMAN; PFRK; PINTO; POF 3; POF3.
Gene ID
668
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat, Bovine
Immunogen
70-120/376
Target
FOXL2
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human FOXL2
Applications
WB, IHC-P, IHC-F, IF
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (WB=1:500-2000), IHC-P (IHC-P=1:100-500), IHC-F (IHC-F=1:100-500), IF (IF=1:100-500)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
668
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