Phospho-eIF4EBP1+2+3 (Thr45) Polyclonal Antibody, FITC Conjugated

Product Specifications

Background

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008].

Synonyms

P-4E-BP1/2/3 Thr 45; p-4EBP1/2/3Thr 45; e4EBP1 phospho T36; e4EBP1 phospho Thr36; p-e4EBP1 Thr36; e4EBP1; Eukaryotic translation initiation factor 4E binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E BP1; 4EBP1; BP 1; BP1; e4E binding protein 1; e4E-binding protein 1; Eukaryotic translation initiation factor 4E binding protein 1; MGC4316; PHAS I; PHASI; PHAS-I; PHAS; 4E-BP1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; Phosphorylated heat and acid stable protein regulated by insulin 1; 4EBP1_HUMAN.

Gene ID

1978

Modification Site

Thr45

Cellular Locus

Cytoplasm

Host

Rabbit

Target

Phospho-eIF4EBP1+2+3 (Thr45)

Clonality

Polyclonal

Isotype

IgG

Conjugation

FITC

Source

KLH conjugated synthetic phosphopeptide derived from human eIF4EBP1 around the phosphorylation site of Thr45

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

494nm/518nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

1978

Predicted Cross Reactivity

Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Guinea Pig

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

APR03890G-01 50 µL

WNT8B Antibody (C-term) [APR03890G]

Ask

View Details

APR03890G-02 100 µL

WNT8B Antibody (C-term) [APR03890G]

Ask

View Details

APR03890G-03 200 µL

WNT8B Antibody (C-term) [APR03890G]

Ask

View Details

APR03890G-04 400 µL

WNT8B Antibody (C-term) [APR03890G]

Ask

View Details

MF-0032077-01 100 mg

APN-C3-PEG4-alkyne

Ask

View Details

MF-0032077-02 500 mg

APN-C3-PEG4-alkyne

Ask

View Details