Deformed Epidermal Autoregulatory Factor 1 Antibody, AbBy Fluor™ 488 Conjugated
Product Specifications
Background
Suppressin, also known as DEAF1 is a transcription factor required for embryonic development. Suppressin contains one SAND domain and one C-terminal MYND-type zinc finger. It interacts with LMO4 and CLIM-2, suggesting that it plays a role mediating cell fate and embryonic pattern formation. Suppressin is expressed in a variety of tissues and localizes to the nucleus. Several isoforms exist due to alternative splicing and, depending on the isoform, Suppressin is secreted in some cell types. Secreted Suppressin can function to inhibit cell proliferation, arresting cells in the G0 or G1 phase. Mutations in the gene encoding Suppressin may result in a growth advantage leading to the development and progression of neoplasia. This suggest that Supressin is a potential target for cancer therapy.
Synonyms
DEAF1; Deformed epidermal autoregulatory factor 1 homolog; Nuclear DEA1 related transcriptional regulator; NUDR; SPN; Suppressin; Zinc finger MYND domain containing protein 5; ZMYND5; DEAF1_HUMAN.
Gene ID
10522
Cellular Locus
Cytoplasm, Nucleus, Secreted
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
211-310/565
Target
Deformed Epidermal Autoregulatory Factor 1
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 488
Source
KLH conjugated synthetic peptide derived from human Deformed Epidermal Autoregulatory Factor 1
Applications
WB, IF (IHC-P)
Purification
Purified by Protein A.
Excitation Emission
499nm/519nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
10522
Predicted Cross Reactivity
Rat, Dog, Cow, Horse, Chicken
Curated Selection
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