E-7386
E-7386 is an orally active CBP/beta-catenin modulator.
Product Specifications
CAS Number
[1799824-08-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/E-7386.html
Purity
98.87
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N([C@](CN1CC2=NC(N3CC(N4CCN(CC)CC4)C3)=CC=C2)([H])N5[C@@H](CC6=CC=C(O)C=C6F)C1=O)N(CC=C)CC5=O)NCC7=CC=CC=C7
Molecular Formula
C39H48FN9O4
Molecular Weight
725.85
Precautions
H302, H315, H319
References & Citations
[1]Yusaku Hori, et al. E7386, an orally active CBP/beta-catenin modulator, induces T cells infiltration into tumor and enhances antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. Cancer Res 2017;77 (13 Suppl) :Abstract nr 5172.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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