KDM5B Polyclonal Antibody, PE Conjugated
Product Specifications
Background
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity) .
Synonyms
CT31; PLU1; PUT1; PLU-1; JARID1B; PPP1R98; RBBP2H1A; Lysine-specific demethylase 5B; Cancer/testis antigen 31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; Retinoblastoma-binding protein 2 homolog 1; RBP2-H1; KDM5B; RBBP2H1
Gene ID
10765
Swiss Prot
Q9UGL1
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Rat
Immunogen
65-165/1544
Target
KDM5B
Clonality
Polyclonal
Isotype
IgG
Conjugation
PE
Source
KLH conjugated synthetic peptide derived from human KDM5B/Jarid1B
Applications
WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
496,564nm/578nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
10765
Predicted Cross Reactivity
Mouse, Dog, Cow, Pig, Horse, Chicken, GuineaPig
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
P9109-28V-ML750 100 µL
MEG2, CT (Tyrosine-protein phosphatase, non-receptor type 9, Protein-tyrosine phosphatase MEG2, PTPase-MEG2) (MaxLight 750) discontinued
Ask
View Details