Phospho-CD32 (Tyr292) Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
Synonyms
CD32; FCG2; CD32B; FCGR2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-b; IgG Fc receptor II-b; CDw32; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; FCGR2B
Gene ID
2213
Swiss Prot
P31994
Modification Site
Tyr292
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Monkey
Target
Phospho-CD32 (Tyr292)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated synthetic phosphopeptide derived from human CD32B around the phosphorylation site of Tyr292.
Applications
WB, ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
2213
Predicted Cross Reactivity
Rat, Dog, Sheep, Pig, Rabbit, Guinea Pig
Curated Selection
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