Phospho-CD32 (Tyr292) Polyclonal Antibody, AbBy Fluor™ 405 Conjugated

Product Specifications

Background

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

Synonyms

CD32; FCG2; CD32B; FCGR2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-b; IgG Fc receptor II-b; CDw32; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; FCGR2B

Gene ID

2213

Swiss Prot

P31994

Modification Site

Tyr292

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse, Monkey

Target

Phospho-CD32 (Tyr292)

Clonality

Polyclonal

Isotype

IgG

Conjugation

AbBy Fluor™ 405

Source

KLH conjugated synthetic phosphopeptide derived from human CD32B around the phosphorylation site of Tyr292.

Applications

WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

401nm/421nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

2213

Predicted Cross Reactivity

Rat, Dog, Sheep, Pig, Rabbit, Guinea Pig

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