SERINC3 Polyclonal Antibody, Cy7 Conjugated
Product Specifications
Background
TDE1, tumor differentially expressed protein 1, is a multi-pass membrane protein also known as serine incorporator 3. Also found on the membranes of the Golgi apparatus within cells, TDE1 is highly expressed in neuronal populations but is also found in thymus, kidney, liver and testis. Expression levels of TDE1 in tumors can be as much as tenfold the amount found in normal tissue of the same type. This increased expression implicates TDE1 as being involved in the cellular transformation from normal to malignant tissue. It is believed TDE1 contributes to oncogenesis by partially protecting cells from serum starvation and etoposide-induced apoptosis. The mechanism through which TDE1 protects cells is poorly understood, but may involve aberrant methylation of TDE1 complexes.
Synonyms
TMS 1; TMS-1; AIGP1; DF33; SBBI99; serine incorporator 3; TDE; TDE1; Tumor dferentially expressed protein 1; SERC3_HUMAN.
Gene ID
10955
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
51-150/473
Target
SERINC3
Clonality
Polyclonal
Isotype
IgG
Conjugation
Cy7
Source
KLH conjugated synthetic peptide derived from human SERINC3
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
743nm/767nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
10955
Predicted Cross Reactivity
Human, Rat, Dog, Cow, Horse, Chicken, Rabbit
Curated Selection
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