Imeglimin
Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function[1].
Product Specifications
CAS Number
775351-65-0
Product Name Alternative
EMD 387008
UNSPSC
12352005
Hazard Statement
H302
Target
Mitochondrial Metabolism; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/imeglimin.html
Concentration
10mM
Purity
99.10
Solubility
DMSO : 32 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=N[C@@H](C)N=C(N(C)C)N1
Molecular Formula
C6H13N5
Molecular Weight
155.20
Precautions
P264-P270-P330-P501
References & Citations
[1]Vial G, et al. Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrialfunction in liver of a high-fat, high-sucrose diet mice model. Diabetes. 2015 Jun;64 (6) :2254-64.|[2]Detaille D, et al. Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. Cell Death Discov. 2016 Jan 18;2:15072.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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