MATK Polyclonal Antibody, APC Conjugated

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. MATK is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.

CHK; Csk homologous kinase; Csk type protein tyrosine kinase; CTK; Hematopoietic consensus tyrosine lacking kinase; HHYLTK; Hydroxyaryl protein kinase; HYL; HYL tyrosine kinase; HYLTK; Leukocyte carboxyl terminal src kinase related; Lsk; Megakaryocyte associated tyrosine kinase; Megakaryocyte associated tyrosine protein kinase; Protein kinase HYL; Tyrosine kinase MATK; Tyrosine protein kinase CTK; Tyrosylprotein kinase; MATK_HUMAN.