Phospho-RUNX2 (Ser451) Polyclonal Antibody, RBITC Conjugated
Product Specifications
Background
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1 (I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity) . Inhibits KAT6B-dependent transcriptional activation.
Synonyms
CCD; AML3; CCD1; CLCD; OSF2; CBFA1; OSF-2; PEA2aA; PEBP2aA; CBF-alpha-1; Runt-related transcription factor 2; Acute myeloid leukemia 3 protein; Core-binding factor subunit alpha-1; Oncogene AML-3; Osteoblast-specific transcription factor 2; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEA2-alpha A; PEBP2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; RUNX2; PEBP2A
Gene ID
860
Swiss Prot
Q13950
Modification Site
Ser451
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human
Target
Phospho-RUNX2 (Ser451)
Clonality
Polyclonal
Isotype
IgG
Conjugation
RBITC
Source
KLH conjugated synthetic phosphopeptide derived from human RUNX2 around the phosphorylation site of Ser451
Applications
WB, FCM
Purification
Purified by Protein A.
Excitation Emission
570nm/595nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
860
Predicted Cross Reactivity
Dog, Cow, Pig, Horse, Chicken
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
RC226577L3V 200 µL
SAR1 (SAR1A) (NM_001142648) Human Tagged ORF Clone Lentiviral Particle
Ask
View Details 
4-20424 Each
Reproductive Tissue Dissociation System 15 (Myometrial), Mouse and Rat
Ask
View Details MBS1258730-01 0.02 mg (E-Coli)
Recombinant Schizosaccharomyces pombe Uncharacterized RNA-binding protein C126.11c (SPCC126.11c)
Ask
View Details MBS1258730-02 0.1 mg (E-Coli)
Recombinant Schizosaccharomyces pombe Uncharacterized RNA-binding protein C126.11c (SPCC126.11c)
Ask
View Details