Phospho-Alpha synuclein (Ser129) Polyclonal Antibody, APC Conjugated
Product Specifications
Background
The synucleins, including Alpha-synuclein (also designated NACP for nonamyloid component precursor), Beta-synuclein (also designated PNP 14 for neuroprotein 14) and Gamma-synuclein (also designated persyn or BCSG1 for breast cancer-specific gene 1) are presynaptic protein abundant in neurons. Alpha-synuclein, a component of Alzheimer?s disease amyloid plaques, is localized to neuronal cell bodies and synapses. Coordinate expression of Alpha-synucleinand Beta-synuclein may be important during hematopoetic cell differentiation. In patients with Parkinson?s disease, a mutant form of Alpha-synuclein has been found and Gamma-synuclein is associated with axonal pathology.
Synonyms
SNCAphospho S129; alpha Synuclein phospho S129 ; alpha-Synuclein Ser129; Synuclein alphaSer129; Alpha synuclein; Alpha-Synuclein; Alpha-synuclein, isoform NACP140; alpha SYN; MGC105443; MGC110988; MGC127560; MGC64356; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid precursor; Non-A-beta component of alzheimers disease amyloid , precursor of; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; PARK 1; PARK 4; PARK1; PARK4; Parkinson disease autosomal dominant, Lewy body 4; Parkinson disease familial 1; PD 1; PD1; Syn; SNCA; Snca synuclein, alpha non A4 component of amyloid precursor; SYUA_HUMAN; Synuclein alpha; Synuclein, alpha non A4 component of amyloid precursor
Gene ID
6622
Modification Site
Ser129
Cellular Locus
Cytoplasm, Nucleus, Cell membrane
Host
Rabbit
Cross Reactivity
Human
Target
Phospho-Alpha synuclein (Ser129)
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC
Source
KLH conjugated synthetic phosphopeptide derived from human SNCA around the phosphorylation site of Ser129 [MP (p-S) EE]
Applications
WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/660nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
6622
Available Sizes
Curated Selection
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