Phospho-TSC1 (Ser505) Polyclonal Antibody, AbBy Fluor™ 555 Conjugated

Product Specifications

Background

Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m (TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.

Synonyms

TSC1phospho S505; LAM; TSC1; Tuberous sclerosis 1 protein.

Gene ID

7248

Modification Site

Ser505

Cellular Locus

Cytoplasm, Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse

Target

Phospho-TSC1 (Ser505)

Clonality

Polyclonal

Isotype

IgG

Conjugation

AbBy Fluor™ 555

Source

KLH conjugated synthetic phosphopeptide derived from human TSC1 around the phosphorylation site of Ser505 [FD (p-S) PF]

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

553nm/568nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

7248

Predicted Cross Reactivity

Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

FHJ14834 100 Tests

Anti-Human VTCN1/B7-H4 Antibody (6H3), PerCP

Ask

View Details

GR105141 100 µg

Genorise® Canine IL-2 polyclonal antibody

Ask

View Details

GTR15213757 1 Vial

Lentiviral mouse Slc14a1 shRNA (UAS) - Lentiviral mouse Slc14a1 shRNA (UAS, RFP) plasmid

Ask

View Details

MBS765875-01 48 Well

Human Pancreas Specific Transcription Factor 1alpha ELISA Kit

Ask

View Details

MBS765875-02 96 Well

Human Pancreas Specific Transcription Factor 1alpha ELISA Kit

Ask

View Details

MBS765875-03 5x 96 Well

Human Pancreas Specific Transcription Factor 1alpha ELISA Kit

Ask

View Details