Phospho-TSC1 (Ser505) Polyclonal Antibody

Product Specifications

Background

Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m (TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.

Synonyms

TSC1phospho S505; LAM; TSC1; Tuberous sclerosis 1 protein.

Gene ID

7248

Modification Site

Ser505

Cellular Locus

Cytoplasm, Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse

Target

Phospho-TSC1 (Ser505)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

KLH conjugated synthetic phosphopeptide derived from human TSC1 around the phosphorylation site of Ser505 [FD (p-S) PF]

Applications

WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Gene ID URL

7248

Predicted Cross Reactivity

Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

S1000-78G2-APC 200 µL

SERPING1, ID (Plasma Protease C1 Inhibitor, C1 Inh, C1Inh, C1 Esterase Inhibitor, C1-inhibiting Factor, C1NH, C1IN) (APC) discontinued

Ask

View Details

AMRe03063-01 50 µL

LAMP2 Rabbit Monoclonal Antibody

Ask

View Details

AMRe03063-02 100 µL

LAMP2 Rabbit Monoclonal Antibody

Ask

View Details

AMRe03063-03 200 µL

LAMP2 Rabbit Monoclonal Antibody

Ask

View Details

MR225620A1V 250 µL

Mouse Prom1 (NM_001163582) AAV Particle

Ask

View Details

pfuse2-rclk2 20 µg

pFUSE2-CLIg-rK2

Ask

View Details