Nicastrin, Human (HEK293, His)

Nicastrin Protein, a crucial gamma-secretase complex subunit, catalyzes intramembrane cleavage of Notch receptors and APP.Operating in Notch and Wnt signaling, the complex modulates regulatory proteins and CTNNB1 levels.Collaborating with PSEN1/2, APH1A/B, and PSENEN/PEN2, Nicastrin binds to proteolytically processed C83 and C99 fragments, emphasizing its pivotal role in molecular pathways and cellular processes.Nicastrin Protein, Human (HEK293, His) is the recombinant human-derived Nicastrin protein, expressed by HEK293 , with C-His labeled tag.

NSVERKIYIP LNKTAPCVRL LNATHQIGCQ SSISGDTGVI HVVEKEEDLQ WVLTDGPNPP YMVLLESKHF TRDLMEKLKG RTSRIAGLAV SLTKPSPASG FSPSVQCPND GFGVYSNSYG PEFAHCREIQ WNSLGNGLAY EDFSFPIFLL EDENETKVIK QCYQDHNLSQ NGSAPTFPLC AMQLFSHMHA VISTATCMRR SSIQSTFSIN PEIVCDPLSD YNVWSMLKPI NTTGTLKPDD RVVVAATRLD SRSFFWNVAP GAESAVASFV TQLAAAEALQ KAPDVTTLPR NVMFVFFQGE TFDYIGSSRM VYDMEKGKFP VQLENVDSFV ELGQVALRTS LELWMHTDPV SQKNESVRNQ VEDLLATLEK SGAGVPAVIL RRPNQSQPLP PSSLQRFLRA RNISGVVLAD HSGAFHNKYY QSIYDTAENI NVSYPEWLSP EEDLNFVTDT AKALADVATV LGRALYELAG GTNFSDTVQA DPQTVTRLLY GFLIKANNSW FQSILRQDLR SYLGDGPLQH YIAVSSPTNT TYVVQYALAN LTGTVVNLTR EQCQDPSKVP SENKDLYEYS WVQGPLHSNE TDRLPRCVRS TARLARALSP AFELSQWSST EYSTWTESRW KDIRARIFLI ASKELE