Beclin 1 Polyclonal Antibody
Product Specifications
Background
This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants.
Synonyms
ATG6; VPS30; beclin1; Beclin 1; BECN1; beclin-1
Gene ID
8678
Swiss Prot
Q14457
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
181-280/450
Target
Beclin 1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human Beclin 1 (NP_003757.1) .
Applications
WB, ELISA, IHC-P, IHC-F, IF, Flow-Cyt
Purification
Purified by Protein A.
Concentration
0.5µg/µl
Dilution
WB (WB=1:500-1000), ELISA (ELISA=1:5000-10000), IHC-P (IHC-P=1:400-800), IHC-F (IHC-F=1:400-800), IF (IF=1:100-500), Flow-Cyt (Flow-Cyt=1:100-500)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Specificity
KO-Validated
Gene ID URL
8678
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