Phospho-IGF1R (Tyr980) Polyclonal Antibody, APC-Cy5.5 Conjugated

Product Specifications

Background

When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Synonyms

IGFR; CD221; IGFIR; JTK13; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; IGF1R

Gene ID

3480

Swiss Prot

P08069

Modification Site

Tyr980

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse

Target

Phospho-IGF1R (Tyr980)

Clonality

Polyclonal

Isotype

IgG

Conjugation

APC-Cy5.5

Source

KLH conjugated synthetic phosphopeptide derived from human IGF1R around the phosphorylation site of Tyr980

Applications

WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

650nm/694nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

3480

Predicted Cross Reactivity

Rat

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

SR421931 1 Kit

Zmiz1 Mouse siRNA Oligo Duplex (Locus ID 328365)

Ask

View Details

GA105176 1 Kit

Human XRCC4 activation kit by CRISPRa

Ask

View Details

TA810461S 30 µL

PLAC2 (TINCR) Mouse Monoclonal Antibody [Clone ID: OTI6C11]

Ask

View Details

MBS8115321-01 0.3 mg

Human B3GALTL HEK293 Overexpression Lysate

Ask

View Details

MBS8115321-02 5x 0.3 mg

Human B3GALTL HEK293 Overexpression Lysate

Ask

View Details

544765 200 µL

A Disintegrin And Metalloproteinase With Thrombospondin 1 (FITC)

Ask

View Details