Phospho-ILK-1 (Thr173) Polyclonal Antibody, HRP Conjugated
Product Specifications
Background
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Synonyms
P59; ILK-1; ILK-2; p59ILK; HEL-S-28; Integrin-linked protein kinase; 59 kDa serine/threonine-protein kinase; ILK; ILK1; ILK2
Gene ID
3611
Swiss Prot
Q13418
Modification Site
Thr173
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Rat
Target
Phospho-ILK-1 (Thr173)
Clonality
Polyclonal
Isotype
IgG
Conjugation
HRP
Source
KLH conjugated synthetic phosphopeptide derived from human ILK-1 around the phosphorylation site of Thr173
Applications
WB, ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
3611
Predicted Cross Reactivity
Mouse, Dog, Cow, Sheep, Pig, Horse, Chicken, Rabbit
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