Phospho-LRP1 (Ser4523) Polyclonal Antibody, HRP Conjugated
Product Specifications
Background
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
Synonyms
APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; Apolipoprotein E receptor; LRP1
Gene ID
4035
Swiss Prot
Q07954
Modification Site
Ser4523
Cellular Locus
Cytoplasm, Nucleus, Cell membrane, Extracellular matrix
Host
Rabbit
Cross Reactivity
Human, Rat
Target
Phospho-LRP1 (Ser4523)
Clonality
Polyclonal
Isotype
IgG
Conjugation
HRP
Source
KLH conjugated synthetic phosphopeptide derived from human LRP1 around the phosphorylation site of Ser4523
Applications
ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Specificity
This is the corresponding phosphorylation site in the following species: mouse ser (4524) rat ser (4524)
Gene ID URL
4035
Predicted Cross Reactivity
Mouse
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