Phospho-LRP1 (Ser4523) Polyclonal Antibody

Product Specifications

Background

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Functions as a receptor for Pseudomonas aeruginosa exotoxin A.

Synonyms

APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; Apolipoprotein E receptor; LRP1

Gene ID

4035

Swiss Prot

Q07954

Modification Site

Ser4523

Cellular Locus

Cytoplasm, Nucleus, Cell membrane, Extracellular matrix

Host

Rabbit

Cross Reactivity

Human, Rat

Target

Phospho-LRP1 (Ser4523)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

KLH conjugated synthetic phosphopeptide derived from human LRP1 around the phosphorylation site of Ser4523

Applications

ELISA, FCM, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

ELISA (1:500-1000), FCM (1:20-100), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Specificity

This is the corresponding phosphorylation site in the following species: mouse ser (4524) rat ser (4524)

Gene ID URL

4035

Predicted Cross Reactivity

Mouse

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