Phospho-IL-1R1 (Tyr496) Polyclonal Antibody, Cy5 Conjugated
Product Specifications
Background
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.
Synonyms
P8; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha; Interleukin-1 receptor type 1; IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; Interleukin-1 receptor type I; IL1R1; IL1RT1
Gene ID
3554
Swiss Prot
P14778
Modification Site
Tyr496
Cellular Locus
Secreted, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse
Target
Phospho-IL-1R1 (Tyr496)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Cy5
Source
KLH conjugated synthetic phosphopeptide derived from human IL-1R1 around the phosphorylation site of Tyr496
Applications
WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
625,650nm/670nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
3554
Predicted Cross Reactivity
Rat, Dog, Pig, Horse
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
K2135604 1.0 µg DNA
SFXN2 sgRNA CRISPR Lentivector (Human) (Target 3)
Sign In for Pricing
View Details 
abx575909 96 Well
Human ADAM Metallopeptidase Domain 8 (ADAM8) ELISA Kit
Sign In for Pricing
View Details 