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Phospho-FXYD1 (Ser88) Polyclonal Antibody, Cy3 Conjugated

Product Specifications

Background

PLM (FXYD1) is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. FXYD2, also known as the gamma subunit of the Na, K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. PLM may be phosphorylated by several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity.

Synonyms

FXYD1 phospho S88; FXYD1 phospho Ser88; p-FXYD1 phospho S88; FXYD domain containing ion transport regulator 1; Phospholemman; PLM; fxyd1; PLM_HUMAN; FXYD domain-containing ion transport regulator 1.

Gene ID

5348

Modification Site

Ser88

Cellular Locus

Cell membrane

Host

Rabbit

Target

Phospho-FXYD1 (Ser88)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Cy3

Source

KLH conjugated synthetic phosphopeptide derived from human FXYD1 around the phosphorylation site of Ser88

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

512,550nm/570,615nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

5348

Predicted Cross Reactivity

Human, Rat, Dog, Cow, Sheep, Pig

Curated Selection

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