Jarid1c Polyclonal Antibody

Product Specifications

Background

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.

Synonyms

KDM5C, MRXJ, MRXSJ, SMCX, XE169

Gene ID

8242

Swiss Prot

P41229

Host

Rabbit

Cross Reactivity

Human, Mouse

Target

Jarid1c

Clonality

Polyclonal

Conjugation

Unconjugated

Source

Polyclonal antibody raised in rabbit against mouse Jarid1c (jumonji, AT rich interactive domain 1C), using 3 KLH-conjugated synthetic peptides containing sequences from the inner part of the protein