TIP5 Polyclonal Antibody
Product Specifications
Background
Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing.
Synonyms
Bromodomain adjacent to zinc finger domain protein 2A, BAZ2A, Transcription termination factor I-interacting protein 5, TTF-I-interacting protein 5, Tip5, hWALp3
Gene ID
11176
Swiss Prot
Q9UIF9
Host
Rabbit
Cross Reactivity
Human, Mouse
Target
TIP-5
Clonality
Polyclonal
Conjugation
Unconjugated
Source
Polyclonal antibody raised in rabbit against TIP5 (Transcription termination factor I-interacting protein 5), using the recombinant protein
Applications
WB, ELISA
Purification
Whole antiserum from rabbit containing 0.05% azide
Concentration
Not Determined
Dilution
WB (1:300-5000), ELISA (1:500-1000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
11176
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