TAF1 Polyclonal Antibody
Product Specifications
Background
Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846) . Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659) . Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607) . Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300) .
Synonyms
TAFII250, p250, BA2R, CCG1, CCGS, TAF2A, KAT4, NSCL2, DYT3
Gene ID
6872
Swiss Prot
P21675
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
TAF1
Clonality
Polyclonal
Conjugation
Unconjugated
Source
Polyclonal antibody raised in rabbit against TAF1 using a KLH-conjugated synthetic peptide.
Applications
WB, IHC-P
Purification
Affinity purification
Concentration
1.15μg/μl
Dilution
WB (1:300-5000), IHC-P (1:200-400)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
6872
Curated Selection
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