Phospho-DOK1 (Tyr362) Polyclonal Antibody
Product Specifications
Background
Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Synonyms
DOK1 phospho Y362; DOK1 phospho Tyr362; p-DOK1 phospho Y362; docking protein 1 downstream of tyrosine kinase 1; Docking protein 1 p62dok Downstream of tyrosine kinase 1 pp62.; docking protein 1 62kD downstream of tyrosine kinase 1; Docking protein 1 62kD; Docking protein 1 62kD; Docking protein 1; DOK 1; DOK1; DOK-1; DOK1_HUMAN; Downstream of tyrosine kinase 1; p62dok; P62DOK; pp62; pp62.
Gene ID
1796
Modification Site
Tyr362
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human
Target
Phospho-DOK1 (Tyr362)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic phosphopeptide derived from human DOK1 around the phosphorylation site of Tyr362
Applications
WB, ELISA, FCM
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), FCM (1:20-100)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
1796
Predicted Cross Reactivity
Mouse, Rat, Dog, Cow, Pig
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS2046839-06 5x 5 mL
APC/CY7-Linked Polyclonal Antibody to Trefoil Factor 2 (TFF2)
Ask
View Details