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Phospho-CRK (Ser41) Polyclonal Antibody

Product Specifications

Background

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Synonyms

P-CRKSer41; p-CRKS41; CRK CRK isoform 2; CRK isoform II; CRKII; p38; Proto oncogene C crk; v crk avian sarcoma virus CT10 oncogene homolog ; v crk sarcoma virus CT10 oncogene homolog; v crk sarcoma virus CT10 oncogene homolog avian; Adapter molecule crk; Avian sarcoma virus CT10 v crk oncogene homolog; CRK_HUMAN.

Gene ID

1398

Modification Site

Ser41

Cellular Locus

Cytoplasm, Cell membrane

Host

Rabbit

Cross Reactivity

Human

Target

Phospho-CRK (Ser41)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

KLH conjugated synthetic phosphopeptide derived from human CRK around the phosphorylation site of Ser41 [DS (p-S) TS]

Applications

WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Product Datasheet

https://www.biossantibodies.com/datasheets/bs-5264R

Gene ID URL

1398

Predicted Cross Reactivity

Mouse, Rat, Dog, Sheep, Pig, Horse, Rabbit

Curated Selection

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