YAP-TEAD-IN-2
YAP-TEAD-IN-2 (compound 6) is a potent YAP-TEAD PPI (protein-protein interaction) inhibitor with IC50 is 2.7 nM[1].
Product Specifications
CAS Number
[2714432-83-2]
UNSPSC
12352005
Target
YAP
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yap-tead-in-2.html
Purity
98.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC[C@]1(CC2=[C@@](C(Cl)=CC=C2O1)[C@@]3=C(C(N)=O)C=CC(OCCOC)=C3F)C4=CC=CC=C4
Molecular Formula
C25H24ClFN2O4
Molecular Weight
470.92
References & Citations
[1]Furet P, et al. The First Class of Small Molecules Potently Disrupting the YAP-TEAD Interaction by Direct Competition. ChemMedChem. 2022 Oct 6;17 (19) :e202200303.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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