HP1 alpha Polyclonal Antibody
Product Specifications
Background
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) . Can interact with lamin-B receptor (LBR) . This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Synonyms
Chromobox protein homolog 5, CBX5, Antigen p25, Heterochromatin protein 1 homolog alpha, HP1 alpha, HP1A
Gene ID
23468
Swiss Prot
P45973
Host
Rabbit
Cross Reactivity
Human
Target
HP1 alpha
Clonality
Polyclonal
Conjugation
Unconjugated
Source
Polyclonal antibody raised in rabbit against human HP1 alpha (Heterochromatin protein 1 homolog alpha), using the full length recombinant GST tagged protein
Applications
WB, IF
Purification
Protein G purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300
Concentration
2µg/µl
Dilution
WB (1:300-5000), IF ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
23468
Curated Selection
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