Alisporivir
Product Specifications
Product Name Alternative
Debio-025; DEB-025
UNSPSC Description
Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
Target Antigen
Cyclophilin; HCV
Type
Reference compound
Related Pathways
Anti-infection;Immunology/Inflammation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Alisporivir.html
Purity
98.85
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O[C@@H]([C@](C(N[C@H](C(N([C@@H](C(N([C@H](C(N[C@H](C(N([C@H]1CC(C)C)C)=O)C(C)C)=O)C(C)C)CC)=O)C)C)=O)CC)=O)([H])N(C([C@@H](N(C([C@](N(C([C@@H](N(C([C@@](NC([C@@H](NC1=O)C)=O)([H])C)=O)C)CC(C)C)=O)C)([H])CC(C)C)=O)C)C(C)C)=O)C)[C@H](C)C/C=C/C
Molecular Weight
1216.64
References & Citations
[1]Coelmont L, et al. DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. PLoS One. 2010 Oct 27;5(10):e13687.|[2]Quarato G, et al. The cyclophilin inhibitor alisporivir prevents hepatitis C virus-mediated mitochondrial dysfunction. Hepatology. 2012 May;55(5):1333-43.|[3]de Wilde AH, et al. Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model. Virus Res. 2017 Jan 15;228:7-13.|[4]Esser-Nobis K, et al. The cyclophilin-inhibitor alisporivir stimulates antigen presentation thereby promoting antigen-specific CD8(+) T cell activation. J Hepatol. 2016 Jun;64(6):1305-14.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, stored under nitrogen, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12559/Alisporivir-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12559/Alisporivir-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
254435-95-5
Available Sizes
Curated Selection
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