5-hmC Monoclonal Antibody (mouse)
Product Specifications
Background
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.
Synonyms
ORC2L, Origin recognition complex subunit 2, ORC2
Gene ID
4999
Swiss Prot
Q13416
Host
Mouse
Cross Reactivity
Human
Target
ORC2
Clonality
Monoclonal
Isotype
IgG1
Clone
.
Conjugation
Unconjugated
Source
Monoclonal antibody raised in mouse against human ORC2, using two recombinant proteins containing the N-terminal and C-terminal part of the protein, respectively
Applications
WB
Purification
Protein G purified monoclonal antibody in PBS containing 0.05% azide.
Concentration
0.6µg/µl
Dilution
WB (1:300-5000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
4999
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