TBP (2C9) Monoclonal Antibody
Product Specifications
Background
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682) . Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682) . Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071) . Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription (PubMed:15970593) . The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.
Synonyms
GTF2D, GTF2D1, SCA17, TF2D, TFIID
Gene ID
6908
Swiss Prot
P20226
Host
Mouse
Cross Reactivity
Human, Mouse
Target
TBP
Clonality
Monoclonal
Isotype
IgG1
Clone
2C9
Conjugation
Unconjugated
Source
Monoclonal antibody raised in mouse against the amino-terminal domain of human TBP (TATA box binding protein) .
Applications
WB
Purification
Monoclonal antibody in PBS containing 0.05% azide; purified by ammonium sulphate precipitation followed by dialysis
Concentration
8µg/µl
Dilution
WB (1:300-5000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
6908
Curated Selection
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