Lamin B Receptor Polyclonal Antibody, FITC Conjugated
Product Specifications
Background
Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization. Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. The cleavage of lamins results in nuclear disregulation and cell death.
Synonyms
PHA; LMN2R; TDRD18; DHCR14B; Lamin-B receptor; Integral nuclear envelope inner membrane protein; LBR
Gene ID
3930
Swiss Prot
Q14739
Cellular Locus
Cytoplasm, Nucleus, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse
Immunogen
1-100/615
Target
Lamin B Receptor
Clonality
Polyclonal
Isotype
IgG
Conjugation
FITC
Source
KLH conjugated synthetic peptide derived from human Lamin B Receptor
Applications
WB, FCM
Purification
Purified by Protein A.
Excitation Emission
494nm/518nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Specificity
The immunogen for this product has partial sequence similarity to SEPT8 and SEPT2
Gene ID URL
3930
Predicted Cross Reactivity
Rat, Cow, Horse, Rabbit
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